It has been nearly a decade since the first DNA-microarray experiments for studying genomic aberrations and inferring copy numbers were first done. Several statistical methods have since evolved providing us with better signal-to-noise ratios and improved detection of copy number aberrations. More recently, the inference on parent-specificcopy numbers (PSCNs) based on SNP microarrays have gained interest and a handful of methods have been proposed. Here we will present a method (Paired PSCBS) that allows us to obtain high-quality PSCNs from a single pair of tumor-normal samples without the use of external references or prior estimates.
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