The ability to read and interpret the human genome is the most rapidly advancing area in all of science, technology and the healthcare industry. I will give a brief overview of the field and its current status, and then focus on the specific problem of finding the genes that cause human disease. There, I will indicate the role that math and scientific computing can play, and mention some specific problems I have worked on with Professor Osher. I will also tell a few strange stories from the front lines of the race to make a machine that can read a human genome for $1000, and the global battle to solve all human disease.