We have conducted an examination of 2054 DNA sequences located throughout the human genome, conserved to at least 70% between human and fugu, and 98% between human and mouse. These sequences were selected to avoid all known coding regions, and therefore we expect compose a set of Conserved
Non-coding Elements (CNEs). The extraordinary conservation of these elements across hundreds of millions of years of divergent evolution seems
to imply substantial functional importance. We explore the evidence for this hypothesis, and, utilizing existing and novel computational methods, attempt to recapitulate regulatory functions coded by the CNEs from analysis of primary sequence data and the tissue expression data of nearby genes. We present both methods and results.
This is a joint work with Peter Bickel, Ben Brown, Na Xu, Kathrina Kechris, Francise Poulin and Eddy Rubin.
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