Yeast has evolved a complex network to regulate its transcriptional program in response to environmental and genetic perturbations. We are interested in how the components of the network are linked together and why specific network structures were chosen. To answer how, we have developed a number of computational algorithms to reconstruct the network by integrating information from functional genomics data and sequences from multiple yeast species. In attempting to answer why, we have focused on small sub-networks that govern specific biological processes and analyzed their behavior quantitatively using mechanistic models. We have also studied the evolution of these sub-networks via comparative genome analysis of multiple yeast species.
Copyright. All Rights Reserved.