The last 40 years have witnessed several dramatic upheavals in our understanding of genomes, from the discovery of RNA splicing in the 1970s to the identification of hundreds of microRNAs and other small noncoding RNAs at the beginning of the 21st century. This four-part series will review basic concepts and techniques in molecular biology, while considering the landmark discoveries and game-changing technological innovations that have punctuated each of the past four decades. Topics covered will include gene structure, transcription and translation, splicing, tumor viruses and reverse transcription, gene regulation, chromatin and epigenetics, RNA interference, small RNAs and post-transcriptional regulation, RNA editing, protein families and phylogenetics, recombinant DNA technology, PCR, DNA sequencing strategies and microarray technology.
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