Institute for Pure and Applied Mathematics

FUNCTIONAL GENOMICS/EXPRESSION ARRAYS

IPAM  Fall 2000

TUTORIALS  

September 19-27, 2000

IPAM Building, UCLA

·     Roger Brent (Molecular Sciences Institute, Berkeley), “Why Biologists Need Mathematicians” (3 lectures Sept. 19-20)

            1. Themes from biological systems.

2. Types of data—how biological information is gathered.

3. Possible issues for mathematicians.

·     Gary Churchill (Jackson Lab): “Experimental Design and Data Analysis for Gene Expression Microarrays" (3 lectures Sept. 23-24)

1. Experimental design.

2. ANOVA

3. Principles illustrated using some of our data.

·     Christopher Lee (UCLA), “Whole Genome Analysis of Sequence Variation--Graph Models of Evidence” (4 lectures Sept. 25-26)

            1-2. Biology of sequence variation—polymorphism among individuals, ribotypes among cells.

            3-4. Role of probability in prediction and in computing confidence levels, graphs as a technique for calculating evidence.

·     Terry Speed (Melbourne and Berkeley): “Overview of Computational Biology for Mathematical Scientists” (11 lectures Sept. 19-27)

1.  The blueprint of life

2.  Molecular biology databases

3.  Sequence analysis of nucleic acids and proteins I: Similarity searches

4.  Sequence analysis of nucleic acids and proteins II: Prediction of

    structure and function

5.  Network analysis of molecular interactions

6.  Some molecular biology

7.  cDNA microarrays on glass slides (an introduction to the

    practicalities)

8.  Image analysis of cDNA microarrays

9. Basic statistical analysis of cDNA microarray data I

10. Basic statistical analysis of cDNA microarray data II

11. Classification and discrimination of cell lines using cDNA microarray

    data

·     Timothy Triche (Children’s Hospital, LA), "Gene Expression Profiling as Indices of Biologic and Clinical Behavior in Cancer: Comparison of Clustering Methods and Correlative Biologic Indicators" (3 lectures Sept. 21-22)

                                                                    Tutorial Daily Schedule

If you are interested in attending or have questions, please e-mail to info@ipam.ucla.edu with “Tutorials” in the subject line.   For directions to IPAM and for further information about the Functional Genomics/Expression Arrays program September 19-December 15, see www.ipam.ucla.edu .

For information on housing refer to www.ipam.ucla.edu/visitor_info/housing.html