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Mathematical and Computational Approaches in High-Throughput Genomics

Workshop I: Next-generation Sequencing Technology and Algorithms for Primary Data Analysis

October 3 - 6, 2011


Organizing Committee | Scientific Overview | Speaker List

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Organizing Committee

Phil Green (University of Washington)
Matteo Pellegrini (University of California, Los Angeles (UCLA), Molecular, Cell, and Developmental Biology)
Aviv Regev (Broad Institute)
Eric Schadt (Pacific Biosciences)
Jay Shendure (University of Washington)
Yun Song (University of California, Berkeley (UC Berkeley))

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Scientific Overview

In just a few years, new technologies for massively parallel DNA sequencing have become widely available, reducing the cost of sequencing a genome by four orders of magnitude and placing the capacity to generate gigabases to terabases of sequence data into the hands of individual investigators. These “next-generation” technologies have the potential to dramatically accelerate biological and biomedical research by enabling the comprehensive analysis of genomes and transcriptomes to become inexpensive, routine and widespread.

This is a dynamic moment in the field. The technologies themselves are evolving at a breathtaking pace, and the exploding volume of data has spurred the development of novel algorithmic approaches for primary analyses of sequence data.

This workshop, the first in a series of five, will bring together leaders in the field to present next-generation sequencing technology and to discuss the various mathematical and computational challenges presented by these technologies. Specifically, we will provide an introduction to the core concepts driving the development of leading second-generation and third-generation technologies. This discussion will be linked to an extensive consideration of methods for base-calling and variant-calling, for aligning reads to reference sequences (e.g. genomes) and for de novo assembly of short reads into longer sequences.

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Confirmed Speakers

Can Alkan (University of Washington)
Srinivas Aluru (Indian Institute of Technology, Bombay)
Mark Depristo (Broad Institute)
Radoje Drmanac (Complete Genomics, Inc.)
Phil Green (University of Washington)
David Haussler (University of California, Santa Cruz (UC Santa Cruz))
Earl Hubbell (Life Technologies)
Rafael Irizarry (Johns Hopkins University)
David Jaffe (Broad Institute)
Steven Jones (BC Cancer Agency)
Jim Kent (University of California, Santa Cruz (UC Santa Cruz))
Daphne Koller (Stanford University)
Jonas Korlach (Pacific Biosciences)
Christopher Lee (University of California, Los Angeles (UCLA))
Ruiqiang Li (Novogene)
Elaine Mardis (Washington University in St.Louis - School of Medicine)
Cristina Pop (Stanford University)
Chirs Saunders (Illumina, Inc. )
Moran Yassour (Broad Institute)
Daniel Zerbino (University of California, Santa Cruz (UC Santa Cruz))

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Contact Us:

Institute for Pure and Applied Mathematics (IPAM)
Attn: GENWS1
460 Portola Plaza
Los Angeles CA 90095-7121
Phone: 310 825-4755
Fax: 310 825-4756
Email: ipam@ucla.edu
Website: http://www.ipam.ucla.edu/programs/genws1/

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