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Workshop I: Multiscale Modeling in Soft Matter and Bio-Physics

September 26 - 30, 2005

IPAM Building
Room 1200

Printable Version

Monday, September 26, 2005

Morning Session

From atomistic detail to (macro) molecular motion

8:00 - 8:50 Check-In/Breakfast (Hosted by IPAM)
8:50 - 9:00 Welcome and Opening Remarks
9:00 - 9:50

Klaus Schulten (University of Illinois at Urbana-Champaign)

""Multiscale simulations of DNA-protein, and protein-lipid complexes"

9:50 - 10:20 Break
10:20 - 11:10

Joel Ireta (Fritz-Haber-Institut der Max-Planck-Gesellschaft)

"IInfinite polypeptides: An approach to study the secondary structure of proteins"
Presentation (PowerPoint File)

11:10 - 12:00

Joan-Emma Shea (UC Santa Barbara)

"Design of Inhibitors of Alzheimer Amyloid-ß Peptide Aggregation"
Presentation (PowerPoint File)

12:00 - 2:00 Lunch (on your own)

Afternoon Session

The coarse-graining approach: new methods and perspectives

2:00 - 2:50

William Gelbart (UCLA)

"Chain translocation in a biological context"
Presentation (PowerPoint File)

2:50 - 3:40

John Maddocks (École Polytechnique Fédérale de Lausanne (EPFL))

"Parametrizations of Coarse-Grain Sequence-Dependent Models of DNA Mechanics"
Presentation (PDF File)

3:40 - 4:10 Break
4:10 - 5:00

Alexander Lyubartsev (University of Stockholm)

"Invese Monte Carlo method for determination of effective potentials for coarse-grained models"
Presentation (PowerPoint File)

5:00 - 7:00 Wine & Cheese Reception and Poster Session

Tuesday, September 27, 2005

Morning Session

Multiscaling and collective behaviors: insights from analytical theories

8:30 - 8:50 Continental Breakfast
9:00 - 9:50

Michael Schick (University of Washington)

"A comparison of two routes to membrane fusion"
Presentation (PowerPoint File)

9:50 - 10:20 Break
10:20 - 11:10

Anatoly Kolomeisky (Rice University)

"Growth Dynamics of Cytoskeleton Proteins: Multiscale Theoretical Analysis"
Presentation (PowerPoint File)

11:10 - 12:00

Steve Plotkin (University of British Columbia)

"How do many-body interactions and transition state structure determine how a protein folds? "

12:00 - 2:00 Lunch (on your own)

Afternoon Session

Water interactions and hydrophobic effect: an intrinsically multiscale problem

2:00 - 2:50

Monte Pettitt (University of Houston)

"Hydrophobicity at different length scales"

2:50 - 3:40

Philip Pincus (UC Santa Barbara)

"Multi-Scale Views of the Hydrophobic Interaction"
Presentation (PowerPoint File)

3:40 - 4:10 Break

Emerging techniques to combine multiple resolutions

4:10 - 5:00

Daniel Zuckerman (University of Pittsburgh)

"Exploring Algorithm Space: Resolution Exchange Simulation and Other Exchange Variants"
Presentation (PowerPoint File)

5:00 - 5:50

Zan Luthey-Schulten (University of Illinois at Urbana-Champaign)

"Using Evolutionary Concepts to Study the Function and Folding of Proteins"


Wednesday, September 28, 2005

Morning Session

From atomistic detail to (macro) molecular motion

8:30 - 9:00 Continental Breakfast
9:00 - 9:50

Angel Garcia (Rensselaer Polytechnic Institute)

"Theoretical Studies of Pressure effects on folding/unfolding of proteins"

9:50 - 10:20 Break
10:20 - 11:10

Mark Tuckerman (New York University)

"Enhanced conformational sampling via novel variable transformation and very large time-step molecular dynamics"

11:10 - 12:00

To Be Announced

12:00 - 6:00 Excursion to the Getty Center: lunch and afternoon visit

Thursday, September 29, 2005

Morning Session

Water interactions and hydrophobic effect: an intrinsically multiscale problem

8:30 - 8:50 Continental Breakfast
9:00 - 9:50

Jeffery Saven (University of Pennsylvania)

"Solvation and the design and engineering of folding molecules"

9:50 - 10:20 Break
10:20 - 11:10

Ken Dill (University of California, San Francisco)

"Statistical mechanical models of water and aqueous solvation"
Presentation (PDF File)

11:10 - 12:00

Nathan Baker (Washington University in St. Louis)

"Multiscale methods for biomolecular electrostatics and diffusion"
Presentation (PowerPoint File)

12:00 - 2:00 Lunch (on your own)

Afternoon Session

Multiscaling and collective behaviors: insights from analytical theories

2:00 - 2:50

Alexander Grosberg (University of Minnesota, Twin Cities)

"How proteins find their target on DNA? Delbruck model revisited"

2:50 - 3:40

Peter Wolynes (University of California, San Diego)

"Recent Successes of Energy Landscape Theory of Protein Folding"

3:40 - 4:10 Break
4:10 - 5:00

David Wales (University of Cambridge)

"Navigating the Energy Landscape: Pathways and Rates"
Presentation Files (Zip Archive)

5:00 - 5:50

Robijn Bruinsma (UCLA)

"Physical Models of Viruses"
Presentation (PDF File)
Presentation (PowerPoint File)


Friday, September 30, 2005

Morning Session

Emerging techniques to combine multiple resolutions

8:30 - 8:50 Continental Breakfast
9:00 - 9:50

Steve Nielsen (University of Texas at Dallas)

"Coarse grained to atomistic mapping algorithm: a tool for multiscale simulations"
Presentation (PowerPoint File)

9:50 - 10:20 Break
10:20 - 11:10

Mike Thorpe (Arizona State University)

"Flexibility in Biomolecules: Beyond Molecular Dynamics"
Presentation (PowerPoint File)

11:10 - 12:00

Kurt Kremer (Max Planck Institute for Polymer Research)

"Linking Structure and Properties: Multiscale Simulations of Macromolecules"
Presentation (PowerPoint File)

12:00 - 2:00 Lunch (on your own)

Afternoon Session

2:00 - 2:50

Arieh Warshel (University of Southern California)

"Multiscale Modeling of Biological Functions"

2:50 - 3:40 Panel Discussion
3:40 - 4:10 Break
4:10 - 5:50 Panel Discussion

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