Sulcus Generation
Denis Riviere
CEA Saclay, France
I will describe a decade-long research program focused on the variability of cortical folding patterns. This program has developed a framework based on artificial neuroanatomists trained to identify sulci from a reference database. The framework enables the matching of cortical surfaces at the scale of individual folds.
Another component of the program is the search for an “alphabet” of folding patterns—that is, a set of indivisible folds. This effort relies on studying cortical folding processes using antenatal imaging, as well as backward simulations of morphogenesis designed to reveal traces of embryologic dimples in the mature cortical surface.
The importance of sulcal-based morphometry is illustrated through a study of the correlates of handedness using asymmetry indices. The results indicate, for example, that the central sulcus is larger in the dominant hemisphere.
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