Sulcus Generation

Denis Riviere
CEA Saclay, France

I will describe a decade long research program focused on the variability of the cortical folding patterns. The program has developed a framework of using artificial neuroanatomists that are trained to identify sulci from a database. The framework leads to
matched cortices at the scale of the folds. Another component of the program is the search for the alphabet of the folding patterns, namely a list of indivisible folds. The search relies on
the study of the cortical folding process using antenatal imaging and on backward simulations of morphogenesis aimed at revealing traces of the embryologic dimples in the mature cortical surface. The importance of sulcal-based morphometry is illustrated by a simple study of the correlates of handedness on asymmetry indices.
The study shows for instance that the central sulcus is larger in the dominant hemisphere.

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