Protein structure prediction using ROSETTA

Ingo Ruczinski
Johns Hopkins University

The initial ROSETTA was a method for ab initio protein structure prediction, developed in David Baker's lab at the University of Washington, starting in the mid/late 1990s. We present the initial steps of the development, and in particular have a closer look at the ROSETTA scoring function. We also discuss the CASP strategies for blind structure prediction (starting with CASP3) and some of the developments since then.

Presentation (PowerPoint File)

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