Applying a multiple capillary substrate and oxygen transport model to drug targeting strategies for cancer chemotherapy

Miranda Teboh-Ewungkem
Lafayette College

In some mathematical models developed to study the localization of large anti-cancer agents within a vascular tumor, the idea that the tumor is viewed as a collection of independent Krogh tissue cylinders is used. I have showed that large-scale interactions (which cannot be accounted for with traditional models) occur within multi-capillary vascular bed and these interactions have significant consequences for transport. The idea is to show how a discretization technique used in multicapillary substrate transport model can be used to account for macromolecules associated with cancer treatment in drug delivery strategies.

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