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Cells and Materials: At the Interface between Mathematics, Biology and EngineeringWorkshop III: Angiogenesis, NeoVascularization and MorphogenesisMay 8 - 12, 2006Organizing Committee:
Luisa Iruela-Arispe
(UCLA)
Scientific BackgroundThe development and life-cycles of all living beings are characterized by striking changes in morphology ranging from cell-differentiation to organ development. Morphogenesis occurs in response to gradients of morphogens whose concentrations determine the pathway cells will take during development. Angiogenesis and neovascularization are a specific example of morphogenesis and describe the recruitment and proliferation of vascular endothelial cells from the existing vascular system in order to develop a new vascular network that provides blood and nutrients to specific tissues. Angiogenesis occurs during the natural course of wound healing and tissue regeneration as well as in fetal development. A pathological form of angiogenesis occurs during tumor growth and the resulting neovasculature is much more leaky than is normally the case. Thus, during tissue regeneration it is desirable to promote angiogenesis while during tumor growth angiogenesis should be suppressed. Angiogenesis involves through a number of biochemical and biophysical pathways that have been extensively studied experimentally although there is still much more work to be done. Mathematical modeling, analysis and numerical simulations of angiogenesis are the subject of current research efforts. In this program, we will bring together experts to discuss the state-of-the-art of this field. The overall structure of the workshop will be as follows: Day 1: Foundations of Angiogenesis (Tutorials) Mathematical approaches: Equations of reaction-diffusion-chemotaxis, stochastic processes, percolation, numerical simulations SpeakersAlexander Anderson (University of Dundee)Bruce Ayati (Southern Methodist University) Victoria Bautch (University of North Carolina) John Dallon (Brigham Young University) George Davis (Texas A&M University - College Station) Jeffrey Essner (Iowa State University) Luisa Iruela-Arispe (UCLA) Yi Jiang (Los Alamos National Laboratory) Howard Levine (Iowa State University) Charles Little (University of Kansas Medical Center) Sharon Lubkin (North Carolina State University) Daphne Manoussaki (Vanderbilt University) Steven McDougall (Heriot-Watt University, Riccarton Campus) Roeland Merks (Ghent University) Mandri Obeyesekere (University of Texas M. D. Anderson Cancer Center) Aleksander Popel (Johns Hopkins University) Don Sakaguchi (Iowa State University) Rocio Sierra-Honigmann (Cedars-Sinai Medical Center) Celeste Simon (University of Pennsylvania) Didier Stainer (University of California, San Francisco) Bill Tawil (Baxter BioSurgery) Mary Wheeler (University of Texas at Austin) Nate Whitaker (University of Massachusetts Amherst) Contact Us:Institute for Pure and Applied Mathematics (IPAM) |
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