This talk will explore the many issues we need to understand in order to predict how to get high performance burning plasmas in fusion power plants. In particular I will explore some of the key challenges in the field and how these are advanced by computational simulation, to help understand the processes involved, numerically test theoretical concepts, and guide behavior in future devices. The talk will be themed against the experimental development and progress towards burning plasma conditions. Topics will range turbulent transport, to Alfvenic plucking of field line strings, macroscopic instability, to understanding violent MegaJoule plasma terminations.
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