Mathematical Models of Traditional and Targeted Chemotherapeutic Approaches

Trachette Jackson
University of Michigan

In the first part of this talk I will present a mathematical model of a two-step approach to cancer chemotherapy involving the use of targeted monoclonal antibody-enzyme conjugates for
the selective activation of anti-cancer prodrugs. This mathematical formulation is used to isolate critical parameters for improving the therapeutic index of this treatment strategy. In the second part of the talk, I will present a mathematical model that addresses the issue of tumor response to traditional and targeted chemotherapeutic
approaches. An important feature of this model formulation is the characterization of the different mechanisms of action by which
anti-cancer agents can initiate the cell death cascade. This model is used to predict the long-term response of tumors to repeated rounds of

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