: In this talk, I will give an overview of what we do at Prescient Design by introducing the concept of lab-in-the-loop de novo antibody design with particular emphasis on its computational side. I will then deconstruct the computational side of lab-in-the-loop design into three major components; generative modeling, computational oracles and active learning. I will then go over why each component is necessary, how each component still requires significant scientific research and what Prescient Design is doing to address these challenges.
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