In this presentation, I will describe a new algorithm, called Gene Regulatory Rules (Grus), for discovering and constructing gene regulatory networks from microarray gene expression and protein-DNA binding information from chromatin immunoprecipitation (ChIP) DNA chip technology. Grus identifies all known and several new yeast cell-cycle regulators, as well as many confirmed and newly discovered synergetic relationships among them. Moreover, Grus assigns all identified regulators to their correct phases, and specifies for each regulatory rule the period of time in which the rule applies, resulting in a temporal regulatory network. Overall, our regulatory network contains new serial gene transcriptional regulations in addition to the known ones.
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